21.4. Imine formation | 合法藥品大搜索

Reactionwithprimaryaminestoformimines...Thereactionofaldehydesandketoneswithammoniaor1º-aminesformsiminederivatives,alsoknownasSchiff​ ...

An imine is a compound that contains the structural unit

An enamine is a compound that contains the structural unit

Both of these types of compound can be prepared through the reaction of an aldehyde or ketone with an amine.

You may have the opportunity to observe the reaction of an aldehyde and ketone with 2,4‑dinitrophenylhydrazine (Brady’s reagent) to form a 2,4‑dinitrophenylhydrozone in the laboratory. This is a classical organic chemistry test to confirm the presence of a carbonyl group. The reaction produces very colourful and bright precipitates of yellow, orange and red.

If you can understand why the two reactions of imine and enamine formation are essentially identical, and can write a detailed mechanism for each one, you are well on the way to mastering organic chemistry. If you understand how and why these reactions occur, you can keep the amount of material that you need to memorize to a minimum.