carbapenems 系列抗生素比較@ 急診小醫師 | 合法藥品大搜索

2014年7月21日—Invanz(ertapenem)是CABAPENEMS裡面,唯一對pseudomonas無效的藥物.對Enterococcus也無效.適合治療院外感染.不適合用於院內感染.

Invanz (ertapenem) [1]是 CABAPENEMS 裡面, 唯一對 pseudomonas 無效的藥物. 對 Enterococcus 也無效. 適合治療院外感染. 不適合用於院內感染. 

https://www.ncbi.nlm.nih.gov/pubmed/17488146[2]

Drugs. 2007;67(7):1027-52. Comparative review of the carbapenems.

Zhanel GG1, Wiebe R, Dilay L, Thomson K, Rubinstein E, Hoban DJ, Noreddin AM, Karlowsky JA. Author information Abstract The carbapenems are beta-lactam antimicrobial agents with an exceptionally broad spectrum of activity. Older carbapenems, such as imipenem, were often susceptible to degradation by the enzyme dehydropeptidase-1 (DHP-1)  脫氫肽水解酶 located in renal tubules and required co-administration with a DHP-1 inhibitor such as cilastatin. Later additions to the class such as meropenem, ertapenem and doripenem demonstrated increased stability to DHP-1 and are administered without a DHP-1 inhibitor. Like all beta-l...