藥學雜誌電子報128期 | 合法藥品大搜索

2016年9月30日—Brosym是第三代頭孢菌素cefoperazone500毫克加上內醯胺抑制...有PT與APTT延長，懷疑是cefoperazone/sulbactam所引起的藥物副作用， ...

Cefoperazone Induced Severe Coagulopathy with PT/INR Prolong and Spontaneous Bleeding: A Case Report

Chia-Ling Yu, Li-Huei Chiang, Chi-Hua Chen Department of Pharmacy, Chang-Gung Memorial Hospital Linkou

Abstract

Here we report a 68-year old female with with TB spondylitis, pneumonia and kidney injury under hemodialysis. After 1 week of cefoperazone/sulbactam (2 g/2 g every 12 hr) therapy for pneumonia, a prothrombin time (PT) and an international normalized ratio (INR) were markedly elevated from baseline with gum bleeding, bruising, coffee ground and hematuria were noted. Brosym was discontinued. Vitamin K1 and fresh frozen plasma were administered. After 3-day therapy with fresh-frozen plasma and vitamin K1 supplement, her coagulopathy with ble...