Alfaxan and how it works | 合法藥品大搜索

Steroids were first recognised to have anaesthetic properties in the 1940s 66, 67. Numerous investigations and iterations of steroid molecular modification have occurred over time in the attempt to create useful formulations of neurosteroid molecules. 63, 64, 65

The first commercially manufactured formulation of neurosteroids was widely used through the 1970s and 1980s in both human and veterinary anaesthesia. Neurosteroid anaesthesia was recognised for its excellent anaesthetic properties and minimal effects on cardiovascular function. 60, 61

In the 1990s it was found that alfaxalone could be solubilised in aqueous solution by first complexing it to large sugar molecules known as cyclodextrins. 56, 57, 58