Ranexa (Ranolazine): Uses, Dosage | 合法藥品大搜索

2020年10月20日—WhatisRanexaandhowisitused?Ranexaisaprescriptionmedicineusedtotreatthesymptomsofchestpain(Angina).Ranexamaybeused ...

The mechanism of action of ranolazine’s antianginal effects has not been determined. Ranolazine has anti-ischemic and antianginal effects that do not depend upon reductions in heart rate or blood pressure. It does not affect the rate-pressure product, a measure of myocardial work, at maximal exercise. Ranolazine at therapeutic levels can inhibit the cardiac late sodium current (INa). However, the relationship of this inhibition to angina symptoms is uncertain.

The QT prolongation effect of ranolazine on the surface electrocardiogram is the result of inhibition of IKr, which prolongs the ventricular action potential.

Patients with chronic angina treated with RANEXA in controlled clinical studies had minimal changes in mean heart rate (<2 bpm) and systolic blood pressure (<3 mm Hg). Similar results were observed in subgroups of patients with CHF NYHA Cl...