Suxamethonium Chloride | 合法藥品大搜索

Succinylcholinechlorideisananalogofacetylcholine.Itisanultrashort-acting,depolarizing-type,skeletalmusclerelaxantforintravenousandintramuscular ...

SCH stimulates both nicotinic and muscarinic cholinergic receptors. Stimulation of muscarinic receptors within the sinus node results in numerous bradyarrhythmias, including sinus bradycardia, junctional rhythms, ventricular escape and asystole.

SCH is a trigger for malignant hyperthermia.

Prolonged exposure of the receptors to SCH results in persistent open receptor channel and ionic fluxes through the ion pore, known as phase II or desensitization blockade. Normal depolarization/repolarization is not possible until SCH is metabolized.

In patients ambulatory soon after surgery, random generalized muscle contractions (fasciculations) have been associated with painful myalgias. Whether pretreating with a subparalyzing dose of a nondepolarizing relaxant before SCH is effective in reducing myalgias continues to be a matter of debate.