【篤實關懷倫理卓越】光田綜合醫院Kuang Tien General Hospital | 合法藥品大搜索

Anticoagulants (eg, warfarin) Warfarin PT increased by 100% after 3 to 4 days; reduce dose of anticoagulant by one third to one half.

Antihypertensives Use with caution with beta blockers or calcium channel blockers because of the possible potentiation of bradycardia, sinus arrest, and AV block.

Azole antifungals/fluoroquinolones/macrolides Reports of QTc prolongation with or without torsades de pointes may occur when used concomitantly with amiodarone.

Cardiac glycosides (eg, digoxin) Digoxin levels are increased and may result in toxicity. Reduce digoxin dose by approximately 50% or discontinue.

Cholestyramine Cholestyramine increases enterohepatic elimination of amiodarone and may reduce its serum levels and t ½ .

CYP3A4 inducers (eg, rifampin) Amiodarone and the metabolite, desethylamiodarone, plasma levels may be reduced, decreasing the pharmacologic effect.

CYP3A4 inhibitors (eg, cimetidine, rit...