藥學雜誌電子報128期 | 合法藥品大搜索

2016年9月30日—一位腎功能不全接受規律血液透析的68歲結核性脊椎炎女性病人，因肺炎接受經驗性抗生素cefoperazone2g+sulbactam2g(Brosym)治療， ...

Cefoperazone Induced Severe Coagulopathy with PT/INR Prolong and Spontaneous Bleeding: A Case Report

Chia-Ling Yu, Li-Huei Chiang, Chi-Hua Chen Department of Pharmacy, Chang-Gung Memorial Hospital Linkou

Abstract

Here we report a 68-year old female with with TB spondylitis, pneumonia and kidney injury under hemodialysis. After 1 week of cefoperazone/sulbactam (2 g/2 g every 12 hr) therapy for pneumonia, a prothrombin time (PT) and an international normalized ratio (INR) were markedly elevated from baseline with gum bleeding, bruising, coffee ground and hematuria were noted. Brosym was discontinued. Vitamin K1 and fresh frozen plasma were administered. After 3-day therapy with fresh-frozen plasma and vitamin K1 supplement, her coagulopathy with ble...