Aggrastat 50 mcgml Solution for infusion | 合法藥品大搜索

Aggrastatshouldbeadministeredwithunfractionatedheparin(dosageasabove)...theAggrastat25microgram/kgdosebolusregimenshouldbeinitiatedatthe ...

Pharmacotherapeutic group: Blood and blood forming organs – antithrombotic agents –antithrombotic agents – Platelet aggregation inhibitors excl. heparin

ATC-Code: B01A C17

Mechanism of action

Tirofiban hydrochloride (tirofiban) is a non-peptidal antagonist of the GP IIb/IIIa receptor, an important platelet surface receptor involved in platelet aggregation. Tirofiban prevents fibrinogen from binding to the GP IIb/IIIa receptor, thus blocking platelet aggregation.

Tirofiban leads to inhibition of platelet function, evidenced by its ability to inhibit ex vivo ADP-induced platelet aggregation and to prolong bleeding time (BT). Platelet function returns to baseline within eight hours after discontinuation.

The extent of this inhibition runs parallel to the tirofiban plasma concentration.

Pharmacodynamic effects

In the 0...