Thiazide | 合法藥品大搜索

Thiazide(/ˈθaɪəzaɪd/)referstobothaclassofsulfur-containingorganicmoleculesandaclassofdiureticsbasedonthechemicalstructureofbenzothiadiazine.

Class of chemical compounds

Thiazide () refers to both a class of sulfur-containing organic molecules[1] and a class of diuretics based on the chemical structure of benzothiadiazine.[2] The thiazide drug class was discovered and developed at Merck and Co. in the 1950s.[3] The first approved drug of this class, chlorothiazide, was marketed under the trade name Diuril beginning in 1958.[3] In most countries, thiazides are the least expensive antihypertensive drugs available.[4]

Thiazide organic molecules are bi-cyclic structures that contain adjacent sulfur and nitrogen atoms on one ring.[5] Confusion sometimes occurs because thiazide-like diuretics such as indapamide are referred to as thiazides despite not having the thiazide chemical structure.[6] When used this way, "thiazide" refers...