Papaverine Injection (Papaverine Hydrochloride Injection ... | 合法藥品大搜索

The symptoms of toxicity from papaverine hydrochloride often result from vasomotor[1] instability and include nausea, vomiting, weakness, central nervous system[2] depression, nystagmus[3], diplopia[4], diaphoresis, flushing, dizziness, and sinus[5] tachycardia[6]. In large overdoses, papaverine is a potent inhibitor of cellular respiration and a weak calcium antagonist[7]. Following an oral overdose of 15 g, metabolic acidosis[8] with hyperventilation, hyperglycemia[9], and hypokalemia[10] have been reported. No information on toxic serum concentrations is available.

Following intravenous overdosing in animals, seizures, tachyarrhythmias, and ventricular fibrillation[11] have been reported. The oral median lethal dose in rats is 360 mg/kg.

To obtain up-to-date informat...