Tolnaftate | 合法藥品大搜索

This chapter provides the description, synthesis, physical properties, pharmacokinetics, and methods of analysis of tolnaftate. As a topical antifungal agent, tohaftate is used for the treatment of various dermatophytes and several forms of microsporon that can cause infectious conditions like Tinea pedis (athletes foot), Tinea cruris (jock itch) and Tinea capitis (body ringworm). Tolnaftate is not effective against Candida albicans or gram negative and gram positive bacteria. Tolnaftate is synthesized by the condensation of N-Methyl-m-tolylamine with 2-Naphthyl chlorothionoformate in the presence of sodium bicarbonate or other dehydrochlorinating agent in acetone solution. It is purified by recrystallization from ethanol. The solubility of tolnaftate in various solvents at room temperature has been reported. It is practically insoluble in water, soluble in 1 in 4000 of ethanol, 1 in 7 of acetone, 1 in 9 of carbon tetrachloride, 1 in 55 of ether and 1 ...