Drug treatment of benign prostatic hypertrophy | 合法藥品大搜索

由PDStricker著作·被引用3次—Prazosin.Prazosinisthemostcommonlyusedalphablocker.Controlledstudiesshowaneffectsuperiortoplaceboonurinarysymptomsaswellasurinaryflow ...

Selective alpha1 adrenergic blocking drugs can be used in patients who do not need urgent surgery. Other indications include patients unwilling to undergo surgery or awaiting surgery, and those in whom surgery is contraindicated. Drug treatment is inappropriate if the patient has any of the serious complications of urethral obstruction.

The alpha blockers work by decreasing the smooth muscle tone of the prostate and bladder neck. They are more effective at relieving obstructive symptoms than irritative symptoms. As alpha1 adrenergic blocking drugs are also antihypertensives, patients may develop hypotension. Caution is advised when prescribing for frail patients and those with a history of syncopal attacks or postural hypotension. Starting treatment at a low dose then increasing it slowly to achieve a balance between symptomatic response and adverse effects is recommended. Once patients are stabilised on treatment, they should be reviewed annually for an examina...