Vecuronium | 合法藥品大搜索

Vecuroniumiscurrentlythemostspecificneuromuscularblockingdruginclinicaluseandisshorteractingthanpancuronium.From:VeterinaryAnaesthesia( ...

Vecuronium (see Fig. 22.6) was the first nondepolarizing NMBA with an intermediate duration of action to be introduced into clinical practice. With both a shorter duration of action and a lack of hemodynamic side effects, it set a standard against which all subsequent NMBAs were compared. Vecuronium is a potent NMBA (ED95 is 0.05 mg/kg) with a duration of action of 40 minutes.35,177,178 Typically, twice the ED95 is administered to facilitate tracheal intubation. Doses of 5 to 6 times the ED95 can be administered for more rapid onset of effect 179 without significant hemodynamic side effects.180

Vecuronium is the 2-desmethyl derivative of pancuronium. The lack of one methyl group at the quaternary ammonium of the 2 position increases its lipid solubility and significantly alters its degree of metabolism. While it undergoes more hepatic metabolism than pancuronium, it is primarily eliminated unchanged in t...