methyldopa (Aldomet) | 合法藥品大搜索

Althoughtheexactmechanismofactionisnotyetunderstood,methyldopaisthoughttolowerbloodpressurebyactivatingreceptors(alpha-2receptors)inthe ...

What is methyldopa? What is methyldopa used for?

Methyldopa is an oral medication used to lower blood pressure[1]. Although the exact mechanism of action is not yet understood, methyldopa is thought to lower blood pressure by activating receptors (alpha-2 receptors) in the central nervous system and by reducing the concentration of epinephrine, norepinephrine, dopamine[2], and serotonin.

Epinephrine, norepinephrine, dopamine, and serotonin are neurotransmitters (chemicals) that nerves use to communicate. Reducing the concentration of these neurotransmitters causes blood vessels to dilate (relax or widen), and, as a result, blood pressure is reduced.

After oral administration maximum reduction in blood pressure occurs in four to six hours. When patients reach an effective dosage, a smooth blood pressure response usually occurs in 12 to 24 hours. Bloo...