Leucovorin rescue of human cancer and bone marrow cells ... | 合法藥品大搜索

由 藥劑部 著作 · 2017 — leucovorin rescue 可預防發生。 腎毒性：高劑量MTX 容易在腎小管沉澱造成腎小管的損害，在酸性尿液及尿. 量少的 ... Read More

... 體免疫疾病病人如接受口服MTX治療，額外補充葉酸或活性葉酸(folinic acid) 皆可 ... 活性葉酸做為葉酸救援(leucovorin rescue) 中和MTX對造血系統之急性毒性。 Read More

Leucovorin (folinic acid) 係tetrahydrofolic acid 的衍生物，. Tetrahydrofolic ... Leucovorin calcium 可緩解在葉酸拮抗劑細胞毒性藥物治療過 ... Leucovorin rescue。 Read More

由 AS LaCasce 著作 · 被引用 11 次 — Successful rescue by leucovorin depends on rapid elimination of MTX by the kidneys, which requires aggressive pretreatment as well as posttreatment hydration ... Read More

由 SW Pitman 著作 · 1977 · 被引用 200 次 — ... and subsequent myelotoxicity in 18 adults receiving high-dose methotrexate with calcium leucovorin rescue (MTX-LCV) weekly in doses of 1-7.5 g/m2. Read More

由 W Wilmanns 著作 · 1980 · 被引用 9 次 — The Leucovorin rescue does under such circumstances can be calculated according to the formula Leucovorin (mg) = 10 x MTX (mg/l) x 0.76 x body weight (kg). Read More

由 J Jolivet 著作 · 1994 · 被引用 13 次 — Leucovorin at 0.2 microM rescued two breast cancer and two non-small cell lung cancer cell lines to a lesser extent following EDX than MTX, but significant rescue ... Read More

由 DM Boarman 著作 · 1990 · 被引用 22 次 — ... be reversed by the reduced folate leucovorin. In this report we investigated the mechanism of leucovorin rescue in the MCF-7 human breast cancer cell line. Read More

Important elements in leucovorin rescue are reactivation of DHFR with depression of cellular dihydrofolate (FH2) and provision of folate substrate to circumvent the ... Read More