Cinnarizine | 合法藥品大搜索

Antihistamine and calcium channel blocker medication

Cinnarizine is an antihistamine and calcium channel blocker of the diphenylmethylpiperazine group.[1] It is prescribed for nausea and vomiting due to motion sickness[2] or other sources such as chemotherapy,[3] vertigo,[4] or Ménières disease.[5]

Cinnarizine was first synthesized as R1575 by Janssen Pharmaceutica in 1955. The nonproprietary name is derived from the cinnamyl substituent on one of the nitrogen atoms, combined with the generic ending "-rizine" for "antihistaminics/cerebral (or peripheral) vasodilators".[6] It is not available in the United States or Canada. It has also been cited as one of the most used drugs for seasickness within the British Royal Navy.[7]

Cinnarizine is predominantly used to treat nausea and vomiting associated with motion sickness,[2] vertigo,[4] Ménières disease,[5] or Cogans syndrome.[8]

In fact, it is one of only a select few drugs that has ...