Rexulti (Brexpiprazole Tablets): Uses | 合法藥品大搜索

2021年3月23日—TreatmentOfSchizophrenia.TherecommendedstartingdosageforREXULTIis1mgoncedailyonDays1to4,takenorallywithorwithoutfood[ ...

Included as part of the PRECAUTIONS section[1].

Elderly patients with dementia[2]-related psychosis[3] treated with antipsychotic[4] drugs are at an increased risk of death[5]. Analyses of 17 placebo-controlled[6] trials (modal duration of 10 weeks), largely in patients taking atypical[7] antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo[8]-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group.

Although the causes of death were varied, most of the deaths appeared to be either cardiovascular[9] (e.g., heart failure[10], sudden death) or infectious (e.g., pneumonia[11]) in nature[12]. RE...