Trough: peak ratio and twenty | 合法藥品大搜索

由HLElliott著作·1994·被引用40次—DEFINITIONOFTROUGH:PEAKRATIO:Appliedtoanantihypertensivedrug,thetermtrough:peakratioprovidesanindexofhowwelltheantihypertensive ...

DEFINITION OF TROUGH: PEAK RATIO: Applied to an antihypertensive drug, the term trough: peak ratio provides an index of how well the antihypertensive effect is sustained over the dose interval. This ratio is usually expressed as a percentage and is determined from the ratio of the blood pressure reduction at trough, i.e. at the end of the dose interval and before the next dose is administered, relative to the blood pressure reduction at the time of the peak drug effect. According to guidelines issued by the United States Food and Drug Administration, 50% is the minimum requirement for an acceptable trough: peak ratio.

Timing of measurement: Unfortunately, the Food and Drug Administration has not produced guidelines describing the methodology, required to define the trough: peak ratio, apart from the requirement that account be taken of placebo effects. However, although the timing of the trough meas...