Alfaxalone | 合法藥品大搜索

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Alfaxalone (3α-hydroxy-5α-pregnane-11,20-dione) is a synthetic neuroactive steroid used to induce and maintain general anesthesia. The anesthetic properties of alfaxalone have been known since 1971,1 and this drug was first marketed in the 1970s as Althesin (by the former Glaxo Laboratories Ltd., Greenford, Middlesex, UK) and Saffan (by the former Schering Plough Animal Health, Welwyn Garden City, UK) for human and veterinary anesthesia, respectively. This original formulation was combined with alfadolone, another neurosteroid with weak anesthetic properties, and dissolved in 20% polyoxyethylated castor oil (Cremophor EL; BASF Corp., basf.com[1]). However, in cats, this vehicle caused serious reactions such as hyperemia, edema of the pinnae and distal thoracic limbs, partial laryngeal spasm, and cyanosis.2 In dogs, common adverse effects included salivation, rhinorrhea, edema ...