Intravenous Administration of Carbetocin Versus Oxytocin for ... | 合法藥品大搜索

Postpartum hemorrhage (PPH) remains a leading cause of maternal mortality and severe morbidity worldwide.1 The increased rate of PPH has been noted in many countries and the primary reason is still uterine atony.2 Compared with physiological expectation, active management of the third stage of labor had been reported to be associated with a 50% reduction in the incidence of PPH.3 There are three components of the active management of the third stage of labor involving oxytocin administration, uterine massage and umbilical cord traction. Though, oxytocin is the most effective medication with few adverse effects, long-acting oxytocin agent (carbetocin) had emerged and was recommended by some institutional guidelines to prevent PPH for women after vaginal delivery or cesarean section.4

Carbetocin is a synthetic oxytocin analogue with similar side effects as oxytocin. However, the molecular structure of carbetocin is di...