Nimodipine in aneurysmal subarachnoid hemorrhage | 合法藥品大搜索

由EKronvall著作·2009·被引用94次—Abstract.Object:Thecalciumantagonistnimodipinehasbeenshowntoreducetheincidenceofischemiccomplicationsfollowinganeurysmalsubarachnoid ...

Object: The calcium antagonist nimodipine has been shown to reduce the incidence of ischemic complications following aneurysmal subarachnoid hemorrhage (SAH). Although most randomized studies have been focused on the effect of the peroral administration of nimodipine, intravenous infusion is an alternative and the preferred mode of treatment in many centers. It is unknown whether the route of administration is of any importance for the clinical efficacy of the drug.

Methods: One hundred six patients with acute aneurysmal SAH were randomized to receive either peroral or intravenous nimodipine treatment. The patients were monitored for at least 10 days after bleeding in terms of delayed ischemic neurological deficits (DINDs) and with daily measurements of blood flow velocities in the mi...