The “Old” and the “New” Antibiotics for MDR Gram ... | 合法藥品大搜索

由IKaraiskos著作·2019·被引用87次—EravacyclineholdspromiseinthetreatmentofinfectionsbyCRAB,witha...MedicinesAgencySPCforceftazidimeavibactam(Zavicefta™),.

Treatment and outcomes of healthcare-acquired infections have been threatened by the worldwide increasing incidence of antimicrobial resistance among Gram-negative bacteria (1). New terminology was launched to describe extensively drug-resistant (XDR) and pan drug-resistant (PDR) Gram-negative microorganisms (2), with very limited treatment options and major representatives Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa (1, 3). Several official reports including those of the World Health Organization (WHO), the Infectious Diseases Society of America (IDSA) and the UK Government in 2015 have designated antimicrobial resistance as one of the major problems affecting human health and health economy (4–6). As a result of the pressure exerted from regulatory bodies and social waves, we have a handful of already launched new antibiotics targeting some of the cu...