Proteoglycans and Glycosaminoglycans | 合法藥品大搜索

由AVarki著作·1999·被引用16次—Thematrixproteoglycansincludesmallinterstitialproteoglycans(decorin,biglycan,fibromodulin),aproteoglycanformoftypeIXcollagen,andoneormore​ ...

Primary contributions to this chapter were made by J.D. Esko (University of California at San Diego).

THE FOCUS OF THIS CHAPTER IS on the structure, biosynthesis, and general biology of proteoglycans. Topics include a description of the major families of proteoglycans, their characteristic polysaccharide chains (glycosaminoglycans), and the pathways involved in their biosynthesis.

The study of proteoglycans dates back to the turn of the twentieth century with investigations of “chondromucoid” from cartilage and anticoagulant preparations from liver (heparin). From 1930 to 1950, great strides were made in analyzing the chemistry of the polysaccharides of these preparations (also known as “mucopolysaccharides”), notably by Karl Meyer and his associates, who described the structure ...