A Trial of Lopinavir–Ritonavir in Adults Hospitalized with ... | 合法藥品大搜索

由BCao著作·2020·被引用4244次—InhospitalizedadultpatientswithsevereCovid-19,nobenefitwasobservedwithlopinavir–ritonavirtreatmentbeyondstandardcare.Futuretrials ...

Patients were assessed for eligibility on the basis of a positive reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assay (Shanghai ZJ Bio-Tec or Sansure Biotech) for SARS-CoV-2 in a respiratory tract sample tested by the local Center for Disease Control (CDC) or by a designated diagnostic laboratory. Male and nonpregnant female patients 18 years of age or older were eligible if they had a diagnostic specimen that was positive on RT-PCR, had pneumonia confirmed by chest imaging, and had an oxygen saturation (Sao2) of 94% or less while they were breathing ambient air or a ratio of the partial pressure of oxygen (Pao2) to the fraction of inspired oxygen (Fio2) (Pao2:Fio2) at or below 300 mg Hg. Exclusion criteria included a physician decision that involvement in the trial was not in the patient’s best interest, presence of any condition that would not allow the protocol to be followed safely, known allergy or hypersensitivity to lopinavir–ritonavir, k...