Pentosan Polysulfate Sodium | 合法藥品大搜索

2015年3月25日—Pentosanpolysulfatesodium(Elmiron)istheonlyoralmedicinethatisFDAapprovedfortreatingthepainanddiscomfortofinterstitialcystitis ...

In double-blind, placebo controlled clinical trials, 38 percent of patients treated with Elmiron for three months reported improvement of their IC/BPS symptoms[1]. In open-label trials, 61 percent of patients reported improvement.

Elmiron is thought to work by restoring a damaged, thin, or “leaky” bladder surface. This surface (glycosaminoglycans, or GAG layer) is composed of a coating of mucus, which protects the bladder wall from bacteria and irritating substances in urine. It is believed that Elmiron functions as a synthetic GAG layer, but the drug’s mechanical action in IC is unknown.

A usual dosage for IC/BPS patients is 100 mg. of Elmiron three times a day, for a total of 300 mg/day.

Some patients report symptom relieve in three to four weeks. For others, it may take up to six months to see improvement. Patients are urged to continue ther...