Thioguanine | 合法藥品大搜索
由GHElgemeie著作·2003·被引用72次—6-Mercaptopurine(6MP)and6-thioguanine(6TG)areanalogsofthenaturalpurines:hypoxanthineandguanine.Bothmercaptopurineandthioguanineare ...
6-Mercaptopurine (6MP) and 6-thioguanine (6TG) are analogs of the natural purines: hypoxanthine and guanine. Both mercaptopurine and thioguanine are substrates for hypoxanthine-guanine phosphoribosyltransferase and are converted into the ribonucleotides 6-thioguanosine monophosphate (6-thioGMP) and 6-thioinosine monophosphate (T-IMP) respectively. The accumulation of these monophosphates inhibits several vital metabolic reactions. Today, these thiopurine bases remain valuable agents for the induction and maintenance of remissions in patients with myelocytic and acute lymphocytic leukemia. Despite their proved clinical importance, 6MP and 6TG have certain therapeutic disadvantages, which have continued to stimulate the search for purine derivatives enhancing therapeutic efficacy. Considerable efforts have been made to prepare other novel mercaptopurine and thioguanine analogs and their nucleosides to improve the anti...
6-Thioguanine | 合法藥品大搜索
6-Thioguanine ≥98% | 154-42-7 | 合法藥品大搜索
Thioguanine (Tabloid) Drug Informaton | 合法藥品大搜索
Thioguanine | 合法藥品大搜索
Thioguanine | 合法藥品大搜索
Thioguanine | 合法藥品大搜索
Thioguanine | 合法藥品大搜索
Tioguanine | 合法藥品大搜索
Tioguanine | 合法藥品大搜索
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