Use of cefoperazone still needs a caution for bleeding from ... | 合法藥品大搜索

Brosym (Cefoperazone 500mg + Sulbactam 500m g)/vial 2PC QD；然而使用4天後 ... Cefoperazone因為NMTT支鏈化學結構抑制Vitamin k epoxide reductase而 ... Read More

由 H Hu 著作 · 2019 · 被引用 8 次 — Cefoperazone/sulbactam has low nephrotoxicity and high safety, but a long-term high-dose use may lead to vitamin K-dependent coagulation ... Read More

由 GR Katukuri 著作 · 2016 · 被引用 12 次 — The chemical structure of cefoperazone contains a side chain of N-​methylthiotetrazole which can inhibit vitamin K metabolism resulting in ... Read More

主成分：每小瓶含cefoperazone sodium 500mg 及sulbactam sodium 500mg 等量 ... 態不良的病患，因缺乏維他命K 而有出血症狀，因此須仔細. 觀察患者狀態（請 ... Read More

由 H Hu 著作 · 2019 · 被引用 8 次 — Cefoperazone/sulbactam has low nephrotoxicity and high safety, but a long-term high-dose use may lead to vitamin K-dependent coagulation ... Read More

The chemical structure of cefoperazone contains a side chain of N-​methylthiotetrazole which can inhibit vitamin K metabolism resulting in hypoprothombinemia. Read More

由 SD Rockoff 著作 · 1992 · 被引用 21 次 — Cefoperazone, an antibiotic commonly used for prophylaxis of infection, has been associated with hypoprothrombinemia and bleeding. To reduce the risk of ... Read More

由 HR Hu 著作 · 2019 · 被引用 8 次 — Fatal Vitamin K-Dependent Coagulopathy Associated with Cefoperazone/​Sulbactam: A Case Report. Drug Saf Case Rep. 2019 Jun 14;6(1):6. doi: ... Read More

由 RSM Wong 著作 · 2006 · 被引用 32 次 — Our patient had adequate dietary vitamin K intake and no liver impairment. The rapid development of clotting derangement after cefoperazone therapy suggested ... Read More

Conclusion: This study found that cefoperazone/sulbactam aggravated bleeding and coagulopathies despite using Vitamin K for prevention. Wesupport the use of​ ... Read More