Combination Effect of Titrated Extract of Centella asiatica and ... | 合法藥品大搜索

由JHPark著作·2019·被引用2次—Purpose:Inourpreviousstudy,wedemonstratedthatbothtitratedextractofCentellaasiatica(TECA)andastaxanthin(AST)haveanti-inflammatoryeffectsina ...

Purpose: In our previous study, we demonstrated that both titrated extract of Centella asiatica (TECA) and astaxanthin (AST) have anti-inflammatory effects in a 5% phthalic anhydride (PA) mouse model of atopic dermatitis (AD). The increasing prevalence of AD demands new therapeutic approaches for treating the disease. We investigated the therapeutic efficacy of the ointment form of TECA, AST and a TECA + AST combination in a mouse model of AD to see whether a combination of the reduced doses of 2 compounds could have a synergistic effect.

Methods: An AD-like lesion was induced by the topical application of 5% PA to the dorsal ear and back skin of an Hos:HR-1 mouse. After AD induction, TECA (0.5%), AST (0.5%) and the TECA (0.25%) + AST (0.25%) combination ointment (20 μg/cm²) were spre...