Nesina (Alogliptin Tablets): Uses | 合法藥品大搜索

NESINAisindicatedasanadjuncttodietandexercisetoimproveglycemiccontrolinadultswithtype2diabetesmellitus[seeClinicalStudies].Important ...

Increased concentrations of the incretin hormones such as glucagon-like peptide[1]-1 (GLP-1) and glucose-dependent insulinotropic polypeptide[2] (GIP) are released into the bloodstream from the small intestine[3] in response to meals. These hormones cause insulin release from the pancreatic beta cells in a glucose-dependent manner but are inactivated by the dipeptidyl peptidase-4 (DPP-4) enzyme within minutes. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, reducing hepatic glucose production. In patients with type 2 diabetes, concentrations of GLP-1 are reduced but the insulin response to GLP-1 is preserved. Alogliptin is a DPP-4 inhibitor that slows the inactivation of the incretin hormones, thereby increasing their bloodstream concentrations and reducing fasting and postprandial[4] glucose concentrations in a glucose-dependent manne...