Onivyde (Irinotecan Liposome Injection) a New Treatment ... | 合法藥品大搜索

由LARaedler著作·被引用1次—Irinotecanliposomeinjectionisatopoisomerase-1inhibitorencapsulatedinalipidbilayerliposome.Topoisomerase-1isanenzymethatrelievestorsionalstrain ...

There is an urgent unmet need for more effective therapies in pancreatic cancer. The American Cancer Society estimated that approximately 49,000 new cases of pancreatic cancer will be diagnosed in the United States in 2015, and more than 40,500 people will die from this cancer.1 Pancreatic cancer is the fourth most common cause of cancer deaths in the United States.2

Survival statistics for patients with pancreatic cancer are dismal, in part because the majority of patients with pancreatic cancer are diagnosed with nonresectable advanced disease; only 4% of patients will be alive 5 years after diagnosis.2,3 Surgery and adjuvant chemotherapy with gemcitabine or 5-fluorouracil (5-FU) confers a small survival advantage, but only for patients with early-stage pancreatic cancer.3 A recent meta-analysis of patients with metastatic pancreatic cancer showed a median overall survival (OS) of 4.6 months (rang...