Protamine sulfate | 合法藥品大搜索

Protamine sulfate is a medication that is used to reverse the effects of heparin.[2] It is specifically used in heparin overdose, in low molecular weight heparin overdose, and to reverse the effects of heparin during delivery and heart surgery.[2][3] It is given by injection into a vein.[2] The onset of effects is typically within five minutes.[1]

Common side effects include low blood pressure, slow heart rate, allergic reactions, and vomiting.[2] Allergic reactions may be severe and include anaphylaxis.[2] The risk is greater in males who have had a vasectomy.[4] While there is no evidence of harm from using during pregnancy it has not been well studied in this group.[5] Protamine works by binding with heparin.[2]

Protamine sulfate was approved for medical use in the United States in 1969.[2] It is on the World Health Organizations List of Essential Medicines.[6] It was originally made from the sperm of salmon (salmine, salmon protamine).[2] It is now mainly made u...