Imine synthesis by oxidation | 合法藥品大搜索

Synthesisofimines...Amildthree-componentreactionofaromaticaldehydes,alkylbromides,andaqueousammoniaasthenitrogensourcegivesiminesinvery ...

Categories: C=N Bond Formation[1] >

Name Reactions

Schmidt Reaction[2]

Schmidt Reaction[3]

Recent Literature

A mild three-component reaction of aromatic aldehydes, alkyl bromides, and aqueous ammonia as the nitrogen source gives imines in very good yields. The reaction conditions are compatible with a range of functional groups. The reaction of aldehydes and aqueous ammonia with epoxides leads to imines bearing a vicinal hydroxyl group regioselectively. J.-M. Huang, J.-F. Zhang, Y. Dong, W. Gong, J. Org. Chem., 2011, 76, 3511-3514.

Neat non-volatile amines react efficiently with various aromatic aldehydes in the absence of any catalyst or solvent, to give imines after a reaction time of eight minutes under microwave irradiation. 1,3-dimethylurea dispersed on montmorillonite K10 is used as an methylamine precursor. L. Paquin, J. Hamelin, F. T...