FK506 (Tacrolimus) | 合法藥品大搜索

FK506(Tacrolimus)iscommonlyusedasanimmunosuppressanttopreventtherejectionoforgantransplants.SimilarlytocyclosporinA(CsA),FK506blocks ...

Calcineurin Inhibitor and Autophagy Inducer

Calcineurin inhibition by FK506[1]

FK506 (also known as Tacrolimus), a commonly used immunosuppressant, is a potent calcineurin inhibitor. Calcineurin is a calcium-dependent enzyme that activates the cytoplasmic nuclear factor of activated T cell (NFAT) by dephosphorylating it. The activated NFAT is then translocated into the nucleus, where it upregulates the expression of cytokines such as interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of the T cell response.

More details[2]

Mode of action:

Similar to cyclosporin A, FK506 blocks the activation of calcineurin through the formation of complexes with immunophilins. FK506 binds to an immunophilin called FK506 binding protein 12 (FKBP12), unlike cyclosporin A which binds to a d...

Tacrolimus (FK506) | 合法藥品大搜索

Tacrolimus(FK506, Prograf)是一種免疫抑制藥物，用於預防及治療器官移植後之排斥作用。Tacrolimus會和細胞內的FK-binding protein 結合，抑制calcineurin的磷酸 ... Read More

FK506Tacrolimus | 合法藥品大搜索

Tacrolimus的安全及有效治療濃度範圍非常狹窄，Tacrolimus劑量或濃度不當可能導致移植排斥現象。毒性濃度的Tacrolimus會引起許多與環孢黴素相同的副作用，像 ... Read More

檢驗項目「普樂可復濃度偵測FK506」健保支付標準 | 合法藥品大搜索

檢驗代號, L72-262, 檢驗組別, 緊急生化組. 檢驗項目, TACROLIMUS/FK506, 檢體種類, Blood. 普樂可復濃度偵測. 檢驗方法, MEIA, 送檢時間, 00:00-24:00/day. Read More

病理檢驗部(Tacrolimus(FK506) ) 臺中榮總全球資訊網Taichung ... | 合法藥品大搜索

2021年4月19日 — Tacrolimus會與稱為FK506 (Tacrolimus)結合蛋白（FKBP's）的蛋白質家族結合，形成一個由FKBP、tacrolimus、calmodulin及calcineurins A和B ... Read More

檢驗項目查詢 | 合法藥品大搜索

檢驗編號, 0521~, 項目名稱, Tacrolimus*(FK506). 更新日期, 2019/7/22, 工作組別, 血清免疫5203或5213；夜間/退件5206或5299. 中文名稱, 血中藥物濃度測定-普樂 ... Read More

彰基腎臟科暨慢性腎臟病衛教中心 | 合法藥品大搜索

2018年8月11日 — 抗排斥藥品：Tacrolimus(FK506) ◎商品名 · 1. 普樂可復是一天服用2次(每12小時服藥一次)之口服藥品。 · 2. 安瑞福是一天服用1次的持續性藥效劑型( ... Read More

臺大醫院器官移植團隊 | 合法藥品大搜索

藥物須知 · 用藥注意事項. “抗排斥藥物”是器官移植絕對不可缺少的藥品。 · Neoral（新體睦軟）. Neoral（新體睦軟） · FK506（普樂可復）. FK506（普樂可復） ... Read More

Prograf (FK506) 移植用藥衛教單張 | 合法藥品大搜索

1994年9月，魏崢醫師領軍的心臟團隊進駐振興醫院，經過多年的努力經營，奠定了振興醫院心臟醫療團隊的專業權威名號，也成為享譽國際的優質醫療團隊，深受 ... Read More

FK506 (Tacrolimus) | 合法藥品大搜索

FK506 (Tacrolimus) is commonly used as an immunosuppressant to prevent the rejection of organ transplants. Similarly to cyclosporin A (CsA), FK506 blocks ... Read More

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