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TheMechanismforRisperidone(Risperdal)InducedHyponatremiainSomePatientsBeingTreatedforSchizophrenia.Summary:Approximately20%of ...

The development of hyponatremia can result from a number of different factors, but one that has been associated in patients with schizophrenia is polydipsia.  In short, polydipsia is either a chronic or intermittent ingestion of large volumes of water, which results in a dilution.  It has been estimated that approximately 20% of psychiatric inpatients (mainly schizophrenic patients) will experience polydipsia with at least 5% of those experiencing water intoxication.1

If severe enough, polydipsia induced hyponatremia can cause a number of disturbances in the central nervous system (CNS) which include delirium, ataxia, seizures, and death.1  Interestingly, antipsychotic therapies used in the management of schizophrenia have been associated with causing this condition.  Those most commonly associated include the first generation or typical antipsychotics and a few of the second generat...