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Tolazamide | 合法藥品大搜索

Tolazamide

TolazamideisanoralbloodglucoseloweringdrugusedforpeoplewithType2diabetes.Itispartofthesulfonylureafamily(ATCA10BB).

 Tolazamide

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Chemical compound

Tolazamide is an oral blood glucose lowering drug used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB).

Tolazemide synthesis:[1]U.S. patent 3,063,903 GB 887886  DE 1196200 

para-Toluenesulfonamide is converted to its carbamate with ethyl chloroformate in the presence of a base. Heating that intermediate with 1-amino-azepane leads to the displacement of the ethoxy group and the formation of tolazemide:[1]

Azepane proper would lead to [13078-23-4].

a b Wright JB, Willette RE (July 1962). "Antidiabetic Agents. N4-Arylsulfonylsemicarbazides". Journal of Medicinal and Pharmaceutical Chemistry. 91 (4): 815–22. doi:10.1021/jm01239a016. PMID 14056414. "Tolazamide". Medline Plus. U.S. National Library of Medicine.

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Tolazamide | 合法藥品大搜索
Tolazamide is an oral blood glucose lowering drug used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB). Read More
Tolazamide | 合法藥品大搜索
Tolazamide is an N-sulfonylurea that is 1-tosylurea in which a hydrogen attached to the nitrogen at position 3 is replaced by an azepan-1-yl group. A hypoglycemic​ ... Read More
Tolazamide: Uses | 合法藥品大搜索
Tolazamide is an oral blood glucose lowering drug of the sulfonylurea class. Tolazamide appears to lower the blood glucose acutely by stimulating the release ... Read More
Tolinase (tolazamide) dosing | 合法藥品大搜索
Medscape - Indication-specific dosing for Tolinase (tolazamide), frequency-​based adverse effects, comprehensive interactions, contraindications, pregnancy​ ... Read More
Tolinase (Tolazamide Tablets): Uses | 合法藥品大搜索
TOLINASE (tolazamide) Tablets are indicated as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) ... Read More
Tolazamide Oral: Uses, Side Effects | 合法藥品大搜索
Tolazamide 250 Mg Tablet Hypoglycemics - Sulfonylureas And Related Non-​Sulfonylureas · Generic Name(S): tolazamide · View Free Coupon. Read More
Tolazamide | 合法藥品大搜索
When this approach fails, oral hypoglycemic agents may be indicated. Tolazamide is a first-generation sulfonylurea. Sulfonylureas may be associated with an ... Read More
Tolazamide | 合法藥品大搜索
Tolazamide: learn about side effects, dosage, special precautions, and more on MedlinePlus. Read More
Tolazamide | 合法藥品大搜索
Tolazamide Description. Tolazamide is an oral blood-glucose-lowering drug of the sulfonylurea class. Tolazamide is a white or creamy-white powder very slightly ... Read More
Tolazamide | 1156-19-0 | 合法藥品大搜索
Tolazamide; CAS Number: 1156-19-0; EC Number: 214-588-3; Synonyms: 1-(​Hexahydro-1H-azepin-1-yl)-3-(p-toluenesulfonyl)urea; find Sigma-Aldrich-T2408​ ... Read More
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