Protamine sulfate: Uses | 合法藥品大搜索

2015年9月30日—Summary.Protaminesulfateisabloodfactorusedwhenthereversaloftheanticoagulanteffectofheparinisnecessaryandforthetreatmentof ...

Protamine sulfate is a blood factor used when the reversal of the anticoagulant effect of heparin is necessary and for the treatment of heparin overdose.

Since its earliest discovery in salmon rine sperm heads in the late 1800s to its formal introduction via US FDA approval in 1939, protamine sulfate has occupied an important therapeutic niche as perhaps the only viable option for reversing the anticoagulant effect of heparin use for over 77 years 1,2. Subsequently, because most invasive surgical procedures involve the routine use of heparin to prevent potentially surgery-complicating blood clotting, most cases of major bleeding in these frequent procedures are managed with the use of protamine sulfate 1. The agent elicits this heparin reversal predominantly via the formation of an inactive complex between the anionic nature of heparin and its own cationic state 1,2,7.

Despite the relative imp...