Colomycin 1 million International Units (IU) Powder for ... | 合法藥品大搜索

Colomycinbyintravenousadministrationisindicatedinadultsandchildrenincludingneonatesforthetreatmentofseriousinfectionsduetoselectedaerobic​ ...

SYSTEMIC TREATMENT

The dose to be administered and the treatment duration should take into account the severity of the infection as well as the clinical response. Therapeutic guidelines should be adhered to.

The dose is expressed in IU of colistimethate sodium (CMS). A conversion table from CMS in IU to mg of CMS as well as to mg of colistin base activity (CBA) is included at the end of this section.

Posology

The following dose recommendations are made based on limited population-pharmacokinetic data in critically ill patients (see section 4.4):

Adults and adolescents

Maintenance dose 9 million IU/day in 2-3 divided doses

In patients who are critically ill, a loading dose of 9 MIU should be administered.

The most appropriate time interval to the first maintenance dose has not been established.

Modelling suggests that loading and maintenance doses of up to 12 MIU may be required in patients with good renal functi...