Lacosamide as treatment for partial epilepsy | 合法藥品大搜索

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由 MA Rogawski 著作 · 2015 · 被引用 124 次 — Currently, lacosamide is the only known antiepileptic drug in clinical practice that exerts its anticonvulsant activity predominantly by selectively enhancing slow ... Read More

由 AC Errington 著作 · 2006 · 被引用 145 次 — Lacosamide (LCM) is anticonvulsant in animal models and is in phase 3 assessment for epilepsy and neuropathic pain. Here we seek to identify cellular actions ... Read More

由 C Kellinghaus 著作 · 2009 · 被引用 75 次 — Lacosamide (LCM) is a novel agent that has been developed as an antiepileptic drug. In vitro studies suggest that LCM modulates ... Read More

由 G Curia 著作 · 2009 · 被引用 83 次 — The mechanism of action of several antiepileptic drugs (AEDs) rests on their ... In contrast, lacosamide facilitates slow inactivation of sodium channels both in ... Read More

Lacosamide has a dual mechanism of action. It also modulates collapsin response mediator protein 2 (CRMP-2), preventing the formation of abnormal neuronal ... Read More

由 MA Rogawski 著作 · 2015 · 被引用 124 次 — Currently, lacosamide is the only known antiepileptic drug in clinical practice that exerts its anticonvulsant activity predominantly by selectively enhancing slow ... Read More

Lacosamide binds to collapsin response mediator protein-2 (CRMP-2), a phosphoprotein which is expressed primarily in the nervous system and is involved in ... Read More

Studies suggest that lacosamide selectively enhances slow inactivation of voltage-gated sodium channels and possibly interacts with collapsin response mediator ... Read More