Dexmedetomidine in anaesthesia practice | 合法藥品大搜索

由KSudheesh著作·2011·被引用116次—Dexmedetomidinehasbecomeofthefrequentlyuseddrugsinanaestheticarmamentarium,alongwithroutineanaestheticdrugs,duetoitshaemodynamic,​ ...

Dexmedetomidine has become of the frequently used drugs in anaesthetic armamentarium, along with routine anaesthetic drugs, due to its haemodynamic, sedative, anxiolytic, analgesic, neuroprotective and anaesthetic sparing effects. Other claimed advantages include minimal respiratory depression with cardioprotection, neuroprotection and renoprotection, thus making it useful at various situations including offsite procedures.[1] α-1 to α-2 ratio of 1:1600 makes it a highly selective α-2 agonist compared to clonidine, thus reducing the unwanted side effects involving α-1 receptors.

High selectivity of dexmedetomidine to α-2A receptors (which mediate analgesia and sedation) has been exploited by various authors in regional anaesthesia practice.

Due to its central sympatholytic effect, dexmedetomidine is useful in blunting haemodynamic responses in perioperative period. It is s...