[Etomidate using a new solubilizer. Experimental clinical ... | 合法藥品大搜索

由ADoenicke著作·1990·被引用26次—Atrandom16volunteersreceivedetomidateinpropyleneglycoloretomidateinlipidemulsionforgeneralanesthesia.Adoseof0.3mgkg-1wasgivenover60 ...

Pain following intravenous injection as well as thrombophlebitis are substantial side effects of etomidate that have been reported from the first clinical study (1972-1973) onwards. Investigations of our own and by Gran et al. have pointed out that injectable etomidate with intralipid as a solvent removes side effects without impairing the good hypnotic action. The idea of using a lipid emulsion as a solvent was presented a few years later, inducing two further studies. METHOD. Both pharmacodynamic (continuous EEG registration) and pharmacokinetic [determination (HPLC) of plasma levels of the active substance] investigations were carried out on volunteers. At random 16 volunteers received etomidate in propylene glycol or etomidate in lipid emulsion for general anesthesia. A dose of 0.3 mg kg-1 was given over 60 s. In a clinical study 100 patients were divided into two independent groups of 50 each. They received either the comm...