Comparison of flutamide and spironolactone in the ... | 合法藥品大搜索

由LCusan著作·1994·被引用229次—Whereasflutamidecausedadramatic(80%)decreaseintotalacne,seborrhea,andhairlossscoreafteronly3monthsoftherapy,spironolactonecausedonlya​ ...

Objective: To compare the clinical efficacy and safety of the pure antiandrogen flutamide and the steroidal derivative spironolactone in the treatment of hirsutism in women.

Design: Fifty-three premenopausal women suffering from moderate to severe hirsutism were randomized into two groups and received either flutamide or spironolactone in association with a triphasic oral contraceptive (OC) pill. Hirsutism, acne, seborrhea, alopecia, and side effects were monitored monthly for a treatment period of 9 months and a follow-up after treatment period of 6 months. Blood samples were taken at each visit for assessment of endocrine, biochemical, and hematologic parameters.

Results: After only 6 months of therapy, flutamide caused a maximal reduction in the hirsutism score to a value within almost normal range; during the same period, spironolactone caused only a 30% reduction of the hirsuti...