Dupilumab (Dupixent) | 合法藥品大搜索

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由 H Harb 著作 · 2020 · 被引用 43 次 — Dupilumab is a humanized IgG4 monoclonal antibody that targets the IL-4 receptor alpha chain (IL-4Rα), common to both IL-4R complexes: type 1 (IL-4Rα/​γc; IL-4 ... Read More

由 J Sastre 著作 · 2018 · 被引用 69 次 — A leading example is dupilumab, a monoclonal antibody targeting the α chain of the interleukin (IL)-4 receptor. Dupilumab inhibits the biological effects of the ... Read More

由 D D’Ippolito 著作 · 2018 · 被引用 18 次 — Dupilumab inhibits IL-4 signaling via the type 1 receptor and both IL-4 and IL-13 signaling via the type 2 receptor. By blocking the IL-4R alpha subunit, dupilumab​ ... Read More

由 H Harb 著作 · 2020 · 被引用 43 次 — Dupilumab is a humanized IgG4 monoclonal antibody that targets the IL-4 receptor alpha chain (IL-4Rα), common to both IL-4R complexes: type ... Read More

Mechanism of action — Mechanism of action[edit]. Dupilumab binds to the alpha subunit of the interleukin​-4 receptor (IL-4Rα), making it a receptor ... Read More

由 H Harb 著作 · 2020 · 被引用 43 次 — Dupilumab is a humanized IgG4 monoclonal antibody that targets the IL-4 receptor alpha chain (IL-4Rα), common to both IL-4R complexes: type ... Read More

Dupilumab is a fully human monoclonal antibody directed against IL‐4Rα to inhibit the signalling of IL‐4 and IL‐13. ... Dupilumab inhibits IL-4 signalling via the ... Read More