加護病房常使用的升壓劑大比拼dopamine V.S levophed ... | 合法藥品大搜索

2020年7月17日—多醫學中心隨機分配研究，一組是dopamine20mcq/kg/min(最大劑量)...如果病患在實驗前已使用升壓劑，就須使用實驗藥物來取代;如果實驗前以 ...

依照2008戰勝敗血症臨床指引，Norepinephrine or dopamine centrally administered are the initial vasopressors of choice.(level of evidence , 1C)。 

不過今年新英格蘭期刊發一表了一篇針對休克病患使用dopamine 或 levophed ，比較兩者在死亡率有無差異!!

此篇研究的背景: Both dopamine and norepinephrine are recommended as first-line vasopressor agents in the treatment of shock. There is a continuing controversy about whether one agent is superior to the other.

研究方法: In this multicenter, randomized trial, we assigned patients with shock to receive either dopamine or norepinephrine as first-line vasopressor therapy to restore and maintain blood pressure. When blood pressure could not be maintained with a dose of 20 μg per kilogram of body weight per minute for dopamine or a dose of 0.19 μg per kilogram per minute for norepinephrine, open-label norepinephrine, epinephrine, or vasopressin could be added. The primary outcome w...