Gleevec (Imatinib Mesylate): Uses | 合法藥品大搜索

Gleevecisoftenassociatedwithedemaandoccasionallyseriousfluidretention[​seeADVERSEREACTIONS].Weighandmonitorpatientsregularlyforsignsand​ ...

Imatinib mesylate is a protein-tyrosine[1] kinase inhibitor that inhibits the BCR-ABL tyrosine kinase, the constitutive abnormal tyrosine kinase created by the Philadelphia chromosome abnormality in CML. Imatinib inhibits proliferation and induces apoptosis[2] in BCR-ABL positive cell lines as well as fresh leukemic cells from Philadelphia chromosome positive chronic myeloid leukemia[3]. Imatinib inhibits colony formation in assays using ex vivo peripheral blood and bone marrow[4] samples from CML patients.

In vivo, imatinib inhibits tumor growth of BCR-ABL transfected murine myeloid cells as well as BCR-ABL positive leukemia lines derived from CML patients in blast crisis.

Imatinib is also an inhibitor of the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-Kit, and inhibits PDGF-and SCF-mediated cellular events. In vitro, imati...