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Repeateddailydosesupto8mg/kg(maximumtotaldose896mg)inadultpatientshavebeenadministeredinclinicaltrialswithnoreporteddose-limitingtoxicity.

Pharmacotherapeutic group: Antimycotics for systemic use, other antimycotics for systemic use, ATC code: J02AX05

Mode of action

Micafungin non-competitively inhibits the synthesis of 1,3-β -D-glucan, an essential component of the fungal cell wall. 1,3-β -D-glucan is not present in mammalian cells.

Micafungin exhibits fungicidal activity against most Candida species and prominently inhibits actively growing hyphae of Aspergillus species.

PK/PD relationship

In animals models of candidiasis, a correlation was observed between exposure of micafungin divided by MIC (AUC/MIC) and efficacy defined as the ratio required to prevent progressive fungal growth. A ratio of ~2400 and ~1300 was required for C. albicans and C. glabrata, respectively, in these models. At the recommended therapeutic dosage of Mycamine, these ratios are achievable for the wild-type distribution of Candida spp.

Mechanism(s) of resistance

As for all antimicrobial ...