Fluconazole Loading Dose Pharmacokinetics ... | 合法藥品大搜索

由LPiper著作·2011·被引用84次—Formanydrugswithprolongedhalflife,aloadingdoseisacommonstrategytoachievethetherapeutictargetafterthefirstdose.Aloadingdose( ...

Invasive candidiasis is a leading cause of morbidity and mortality in critically ill infants.1 Prompt administration of antifungal therapy can improve outcomes in candidemic patients.2,3 Despite prompt therapy, 20% of young infants with candidiasis die as a result of invasive disease.4,5

Fluconazole is used frequently in infants for empiric antifungal therapy due to its excellent activity against Candida species, long half life, and low protein binding that allows for high cerebral spinal fluid penetration.6 In adults, effective fluconazole pharmacokinetic/pharmacodynamic (PK/PD) indices for the treatment of candidiasis have been described.7–10 A minimum (total drug) area under the curve (AUC) of 400 mg*hr/L ensures that the PK/PD index of AUC/minimum inhibitory concentration (MIC) stays >50 for Candida species with an MIC breakpoint ≤8 µg/mL.11–13

To reach the drug exposure target AUC of ≥400 mg*hr/L in critically ill infants, dosages of 12 ...