Tybost (cobicistat) dosing, indications | 合法藥品大搜索

Read More

Cobicistat is a mechanism-based inhibitor of cytochrome P450 3A (CYP3A) isoforms. Inhibition of CYP3A-mediated metabolism by cobicistat increases the ... Read More

Cobicistat, sold under the brand name Tybost, is a medication for use in the treatment of human immunodeficiency virus infection (HIV/AIDS). Its major mechanism of action is through the inhibition of human CYP3A ... Read More

由 ED Deeks 著作 · 2014 · 被引用 78 次 — Cobicistat (Tybost™) is a mechanism-based inhibitor of cytochrome P450 (CYP) 3A enzymes that is indicated in the EU as a pharmacokinetic enhancer (i.e. ... Read More

由 BM Shah 著作 · 2013 · 被引用 59 次 — Cobicistat is a new pharmacokinetic booster that is a selective inhibitor of cytochrome P450 3A, the main metabolizing pathway of several ... Read More

由 L Xu 著作 · 2010 · 被引用 142 次 — ... kinact and KI are presented in Table 2. These results suggest that RTV and 3 share the same mechanism of action for the inhibition of CYP3A ... Read More

由 N von Hentig 著作 · 2016 · 被引用 24 次 — Mechanisms of action. Ritonavir was designed in the early 1990s as an HIV PI in order to inhibit the dissection of viral protein precursors of HIV-1- ... Read More

Medscape - Pharmacokinetic enhancer dosing for Tybost (cobicistat), frequency-​based adverse effects, comprehensive interactions, ... Mechanism of Action. Read More

2012年10月15日 — Cobicistat is an inhibitor of cytochrome P450 3A (CYP3A) enzymes. It has no activity against HIV but is intended for use as a pharmacokinetic ... Read More

TYBOST® (cobicistat) tablets, for oral use. Initial U.S. Approval: ... Complex or unknown mechanisms of drug interactions preclude ... 12.1 Mechanism of Action. Read More