Anidulafungin compared with fluconazole for treatment of ... | 合法藥品大搜索

由ACReboli著作·2011·被引用92次—However,theechinocandinanidulafunginwasrecentlydemonstratedtobemoreeffectivethanfluconazoleforsystemicCandidainfectionsina ...

Background: Candida albicans is the most common cause of candidemia and other forms of invasive candidiasis. Systemic infections due to C. albicans exhibit good susceptibility to fluconazole and echinocandins. However, the echinocandin anidulafungin was recently demonstrated to be more effective than fluconazole for systemic Candida infections in a randomized, double-blind trial among 245 patients. In that trial, most infections were caused by C. albicans, and all respective isolates were susceptible to randomized study drug. We sought to better understand the factors associated with the enhanced efficacy of anidulafungin and hypothesized that intrinsic properties of the antifungal agents contributed to the treatment differences.

Methods: Global responses at end of intravenous study treatment in patients with C. albicans infection were compared post-hoc. Multivariate logistic regression analyses wer...