Therapeutic drug monitoring of voriconazole for treatment and ... | 合法藥品大搜索

由SAllegra著作·2018·被引用16次—Inpatientsaged2–11years,thepackageleafletrecommendsaweight‐baseddoseof9mgkg–1IVorPOtwicedailyandamaximumdoseof350mg.Inpatients ...

Abstract

Voriconazole therapeutic drug monitoring is not consistently recommended due to its high interpatient and intrapatient variability. Here, we aimed to describe our experience with voriconazole for treatment and prophylaxis of invasive fungal infections in paediatric patients. A fully validated high‐performance liquid chromatography–mass spectrometry method was used to quantify voriconazole concentration in plasma, at the end of dosing interval. A high interindividual variability was shown. We enrolled 237 children, 83 receiving intravenous and 154 oral voriconazole. A positive correlation between drug dose and drug plasma exposure was observed. Considering intravenous route, patients with higher serum creatinine had higher voriconazole concentrations; a positive correlation was found among drug exposure and age. Sex significantly influenced drug levels: males had higher median drug concentrations than females (P < 0.001). Close voriconazole pharmacokinetics monitoring sho...

Therapeutic drug monitoring (TDM) of antifungal agents ... | 合法藥品大搜索

Voriconazole · 由 HR Ashbee 著作 · 2014 · 被引用 453 次 — If therapy is initiated with oral voriconazole, a loading dose of 400 mg twice daily for two doses is used (for individuals >40 kg), followed ... Read More

Voriconazole dosing and therapeutic drug monitoring in ... | 合法藥品大搜索

由 A Boast 著作 · 2016 · 被引用 27 次 — This study describes our experience with voriconazole, focusing on dosing regimens, dose adjustment and TDM. Methods. We reviewed the ... Read More

Individualized Medication of Voriconazole | 合法藥品大搜索

由 K Chen 著作 · 2018 · 被引用 29 次 — TDM of VRZ is recommended to be repeated when adjusting the VRZ dosing regimen, patients show a poor clinical response or VRZ adverse events, or when ... Read More

Therapeutic Drug Monitoring of Antifungal Agents | 合法藥品大搜索

ANTIFUNGAL THERAPEUTIC DRUG MONITORING RECOMMENDATIONS FOR. ADULT AND ... Changes in voriconazole dosing or route, GVHD with diarrhea ... Levels greater than 5.5 mcg/mL should prompt dose reduction to minimize ... Read More

Impact of dose adaptations following voriconazole therapeutic ... | 合法藥品大搜索

由 VJ Lempers 著作 · 2019 · 被引用 8 次 — Although Therapeutic Drug Monitoring (TDM) of voriconazole is ... 55 and 12 out of 45) therapeutic targets were attained after dose adjustment. Read More

Voriconazole dosing and therapeutic drug ... | 合法藥品大搜索

由 A Boast 著作 · 2016 · 被引用 27 次 — This warrants repeated TDM throughout treatment. Standardized guidelines for TDM and dose adjustment are required in children. Read More

Practice guidelines for therapeutic drug monitoring of ... | 合法藥品大搜索

由 Y Hamada 著作 · 2013 · 被引用 92 次 — Practice guidelines for therapeutic drug monitoring of voriconazole: a ... Patients with liver dysfunction: Dosage adjustments are necessary for ... Read More

Therapeutic drug monitoring of voriconazole for treatment and ... | 合法藥品大搜索

由 S Allegra 著作 · 2018 · 被引用 16 次 — In patients aged 2–11 years, the package leaflet recommends a weight‐based dose of 9 mg kg–1 IV or PO twice daily and a maximum dose of 350 mg. In patients ... Read More

Voriconazole and posaconazole therapeutic drug monitoring ... | 合法藥品大搜索

由 MY Whitley 著作 · 2017 · 被引用 40 次 — Subsequent levels were more likely to be therapeutic after dose adjustments (OR 3.31; 95% CI 1.3–8.6; p = 0.02), regardless of timing of initial ... Read More

Abstract | 合法藥品大搜索

Although therapeutic drug monitoring (TDM) of voriconazole is recommended, no established dosing guidelines have been elucidated. The objective of this ... Read More

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